A linearized non-isothermal general rate model for studying thermal effects in liquid chromatographic columns

A linearized non-isothermal general rate model is formulated and analytically solved to quantify the effects of temperature variations in fixed-bed chromatographic columns. The contains a set four coupled PDE accounting for energy transfer resistances, inner outer particle-pore diffusions, interfacial mass axial dispersion. Laplace transform, eigenvalue-decomposition technique, conventional technique solutions ODE are jointly employed solution equations. few numerical test studies considered assess impact system parameters on performance packed-bed adsorption To access range applicability get scope appropriateness calculated analytical results, results also obtained by applying high resolution finite volume scheme. can be used as an invaluable tool analyzing, optimizing, upgrading liquid procedures.